What prompted Calhoun's resignation from the Vice Presidency?

Calhoun's resignation from the Vice Presidency was primarily prompted by his support for nullification, reflecting a fundamental disagreement with President Andrew Jackson over issues related to federal and state power. Nullification was the idea that states had the right to invalidate any federal law they deemed unconstitutional, a concept that Calhoun championed as a way to protect states’ rights, particularly in the context of the Tariff of 1828, which many in the South, including Calhoun, saw as harmful.

While Calhoun did face personal conflicts, such as social issues involving his wife that led to tensions with Jackson, the most significant factor driving his resignation was his political stance and the divisive nature of nullification. Calhoun's increasing estrangement from the Jackson administration culminated in his resignation, marking a pivotal moment in his political career and shaping the evolving discourse on federal versus state power in the United States.